Redefining the Cell Surface Interactome: Strategic Advanc...

2025-10-21

This thought-leadership article explores how the Sulfo-NHS-SS-Biotin Kit is revolutionizing the study of dynamic cell surface architectures, including emerging domains involving glycoRNAs and RNA-binding proteins. By blending mechanistic insight with strategic experimental guidance, we delineate how water-soluble, reversible biotinylation enables precise, unbiased mapping of cell surface interactomes—advancing both discovery biology and translational pipelines. Building on recent breakthroughs in surface glycoRNA and RBP biology, this article provides translational researchers with actionable frameworks to leverage Sulfo-NHS-SS-Biotin for next-generation purification, profiling, and targeted intervention.